NICE guidance is designed and developed for the NHS in England and is therefore not automatically applicable to Northern Ireland. Guidance is locally reviewed for applicability to Northern Ireland and, where appropriate, is endorsed for implementation in health and social care. THE LOCAL REVIEW DOES NOT REASSESS THE CLINICAL AND COST EVIDENCE USED BY NICE IN FORMING ITS ADVICE. The Department’s link with NICE has ensured that Northern Ireland has access to up-to-date, independent, professional, evidence-based guidance on the value of health care interventions.